In this study, researchers conducted a comparative analysis of cotrimoxazole preventive therapy (CPT) in Malawi, Uganda and Zambia. They held 47 in-depth interviews to examine the influence of context, evidence and the links between researcher, policy makers and those seeking to influence the policy process. In relation to context, they found a number of factors to be influential, including government structures and their focus, funder interest and involvement, healthcare infrastructure and other uses of cotrimoxazole and related drugs in the country. In terms of the nature of the evidence, the researchers found that how policy makers perceived the strength of evidence behind international recommendations was crucial (if evidence was considered weak then the recommendations were rejected). Finally, the links between different research and policy actors were considered of critical importance, with overlaps between researcher and policy maker networks crucial to facilitate knowledge transfer. Within these networks, in each country the policy development process relied on a powerful policy entrepreneur who helped get CPT onto the policy agenda.
Monitoring equity and research policy
Fair Research Contracting equips research partners with key resources on how to build sustainable, equitable global research partnerships. The rise in international research partnerships means that developing countries need to be better positioned to deal with complexities in collaborative research contracting. COHRED argues that better contract negotiation expertise in LMIC institutions will help improve the distribution of benefits of collaborative research, such as overhead costs, data ownership, institutional capacity in research management, technology transfer, and intellectual property rights. With this in mind, COHRED has developed guidance aimed at optimising research institution building through better contracts and contracting in research partnerships. The guidance highlights the key issues for consideration when entering into formalised research partnerships, and provides tools and resources for negotiating fairer research contracts.
The World Health Organisation’s (WHO) Consultative Expert Working Group on Research and Development (CEWG) has proposed the adoption of a convention which would incorporate a mechanism for resource distribution, pooling of funds and global coordination to help developing countries with the research and development for their public health systems. In its draft report to WHO, it argued that intellectual property rights and other incentives, such as financial mechanisms and coordination among stakeholders, are needed to ensure research and development lead to relevant and affordable medical innovations for poor patients. Responses to the report have been typically polarised among WHO Member States, with developing countries expressing strong support and industrial nations taking a more cautious approach. Before the formal negotiations of a convention can start, though, a number of variables are still to be considered, such as the need to table a procedural resolution to take note of the report and to request time before engaging in further negotiations.
Researchers are designing a new model for determining the demographic impact of HIV and AIDS in South Africa. Modelers Leigh Johnson of the Centre for Infectious Disease Epidemiology and Research and Rob Dorrington of the Centre for Actuarial Research at the University of Cape Town have launched the ASSA 2008 model, which has replaced the ASSA 2003 model for estimating HIV prevalence, HIV-related deaths, the numbers of those in need ofanti-retrovirals (ARVs) and the impact of HIV interventions. According to Johnson, the reason the model needed to be updated was because the prevalence data projected was no longer correct because of the new data that emerged from South Africa’s antenatal HIV-prevalence survey. The survey increased the number of women who were tested for HIV and was thus more representative, although there was very little difference in the HIV prevalence results across the board from the ASSA 2003 and 2008 models. ASSA 2008 takes into account new epidemiological data to allow for more accurate projections of HIV prevalence and impact of interventions. It includes the ARV rollout data for up to the end of 2008. Because data shows that two-thirds of people starting ARVs are females, the ASSA 2008 model allows for different rates of ARV initiation in males and females, as well as for children and adults.
IDRC and South Africa’s National Research Foundation (NRF) have announced a new research chairs initiative. The OR Tambo Africa Research Chairs Initiative, named after Oliver Reginald Tambo, the pre-eminent South African leader and advocate of science and technology, will support up to 10 top researchers from across Africa over the next five years. Through international and regional strategic partnerships, the Chairs will contribute to the development of long-term mutually beneficial research collaborations on the continent. They will focus on world-class research in diverse fields and on training graduate students at leading universities in the 15 sub-Saharan African countries that make up the Science Granting Councils Initiative (SGCI), a collaboration between IDRC, NRF, the Swedish International Development Cooperation Agency, and the UK’s Department for International Development. The application and selection process will be conducted using a two-phase approach coordinated by NRF, which will also manage the Chairs once awarded. The call for institutional expressions of interest was launched in December 2018 and the call for detailed chair-holder applications will be launched in May/June 2019. Councils participating in SGCI are expected to play a key role in the research and grants management, implementation, and sustainability of the Chairs.
The World Health Organisation (WHO) has launched a new data portal to track progress towards universal health coverage (UHC) around the world. The portal shows where countries need to improve access to services, and where they need to improve information. The portal features the latest data on access to health services globally and in each of WHO’s 194 Member States, along with information about equity of access. In 2017 WHO will add data on the impact that paying for health services has on household finances. The portal shows that less than half of children with suspected pneumonia in low income countries are taken to an appropriate health provider. Of the estimated 10.4 million new cases of tuberculosis in 2015, 6.1 million were detected and officially notified in 2015, leaving a gap of 4.3 million. High blood pressure affects 1.13 billion people. Over half of the world's adults with high blood pressure in 2015 lived in Asia. Around 24% of men and 21% of women had uncontrolled blood pressure in 2015. About 44% of WHO’s member states report having less than 1 physician per 1000 population. The African Region suffers almost 25% of the global burden of disease but has only 3% of the world’s health workers.
Health systems research has the potential to produce dramatic improvements in health worldwide and to meet some of the major development challenges in the new millennium. Effective research could prevent half of the world's deaths with simple and cost-effective interventions, the World Health Organization (WHO) says in a new World Report on global health research. The WHO World Report on Knowledge for Better Health: Strengthening Health Systems highlights aspects of health research that, if managed more effectively, could produce even more benefits for public health in future. It sets out the strategies that are needed to reduce global disparities in health by strengthening health systems.
The World Intellectual Property Organisation (WIPO), in conjunction with the World Health Organisation, private sector and foundation partners, is preparing to launch a new voluntary database for the sharing of intellectual property for research and development (R&D) on medicines, vaccines and diagnostics for neglected diseases. The project will target least-developed countries and is likely to include a database and a space for creating partnerships. But budget, oversight and the role of member states are still unclear. The aim of the initiative is to boost discovery and development of medicines, vaccines and diagnostics for neglected tropical diseases plus malaria and tuberculosis through greater availability of intellectual property to researchers.
Health research is indispensable for improving health and health equity and contributing to overall development. Many developing countries have made substantial investments in building and enhancing their capacities for research in health and related fields, and these efforts have been supported and extended by programmes of development agencies and research institutions located in high-income countries. Despite decades of such efforts, and notwithstanding some notable examples of success, the overall picture of progress is a mixed one.
The growing global burden of non-communicable diseases in poor countries and poor populations has been neglected by policy makers, major multilateral and bilateral aid donors, and academics. Despite strong evidence for the magnitude of this burden, the preventability of its causes, and the threat it poses to already strained health care systems, national and global actions have been inadequate. A full range of policy responses is required from government and non-governmental agencies, but unfortunately the capacity and resources for this response are insufficient, and governments need to respond appropriately.